产品货号：
Z18968
中文名称：
IRE1/ERN1抗体
英文名称：
Anti-IRE1/ERN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IRE1/ERN1 Antibody |
| 指标别名 | ERN1;hIRE1p;Inositol requiring protein 1;IRE1;Ire1 alpha;IRE1;ERN1;IRE1P;IRE1α |
| 克隆性 | Polyclonal |
| 检验物种 | Human |
| 应用范围 | WB,IHC,Direct ELISA |
| 基因名称 | ERN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human IRE1/ERN1 recombinant protein (Position:S370-G567). |
| 实际分子量 | 130KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is an enzyme that in humans is encoded by the ERN1 gene.This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1.The encoded protein contains two functional catalytic domains,a serine/threonine-protein kinase domain and an endoribonuclease domain.This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR).The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins,regulating protein synthesis and activating molecular chaperones.This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. |
| Uniprot ID | O75460 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | endoplasmic reticulum to nucleus signaling 1 |
| 蛋白名全称 | Serine/threonine-protein kinase/endoribonuclease IRE1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Direct ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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